Fourth instalment of the comedy franchise. Over a decade after the events of 'American Pie' (1999), the gang descend on their home town of East Great Falls, Michigan for their ten-year high school reunion. Over the course of a wild weekend, chaos ensues as Jim (Jason Biggs), Stifler (Seann William Scott), Oz (Chris Klein) and Finch (Eddie Kaye Thomas) reconnect.

Jim and Michelle (Alyson Hannigan) are still married but problems arise when their next door neighbour develops a crush on Jim. Meanwhile, Stifler is stuck in a dead-end temping job and is having a hard time with the ladies, Oz has hit the big time after winning a TV talent show and Finch is still hankering after Stifler's mother.