PCDAA rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES14231-50, ES14231-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008],

Alternate Name: Protocadherin alpha-10 (PCDH-alpha-10)

Source: Rabbit

Applications: WB

Dilution: WB 1:500-2000

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized peptide derived from human PCDAA AA range: 302-352

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 105kD

Human Gene ID: 56139

Human SWISS Prot NO: Q9Y5I2

Subcellular Location: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

Research Use Only