FKBP12 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90516-50, BS90516-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P62942(Human) P26883(Mouse) Q62658(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC/IF

All Applications: WB:1:500-1:1,000
ICC:1:100-1:500

Background: Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin. FKBP12.6, also known as FK506-binding protein 1B, is a 108 amino acid immunophilin belonging to the FKBP-type PPIase family. Subcellularly localized to the cytoplasm, FKBP12.6 binds to RyR in cardiac muscle sarcoplasmic reticulum and possibly plays a unique physiological role in excitation-contraction coupling in cardiac muscle. FKBP12.6 also catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Ubiquitously expressed, FKBP12.6 is found at highest levels in brain and thymus. FKBP12.6 is expressed as two isoforms produced by alternative splicing.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: FKBP12 polyclonal antibody detects endogenous levels of FKBP12 protein.

Bioworld Molecular Weight: 12 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of FKBP12 on different cells lysates using anti-FKBP12 antibody at 1/500 dilution.
Positive control: Line 1: SH-SY5Y Line 2:V937, ICC staining FKBP12 in A431 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: PPIase FKBP1A, 12 kDa FKBP, FKBP-12, FKBP-1A, FKBP1A, 12 kDa FK506-binding protein, 12 kDa FKBP, Calstabin 1, FK506 binding protein 1, FK506 binding protein 12, FK506 binding protein 1A (12kD), FK506 binding protein 1A 12kDa, FK506 binding protein 1A, FK506 binding protein T cell 12 kD, FK506 binding protein, T cell, 12 kD, FK506 binding protein12, FK506-binding protein 1A, FKB1A, FKBP 12, FKBP 1A, FKBP-12, FKBP-1A, FKBP1, FKBP12, FKBP12 Exip3, FKBP12C, fkbp1a, Immunophilin FKBP12, Peptidyl prolyl cis trans isomerase, Peptidyl-prolyl cis-trans isomerase FKBP1A, PKC12, PKCI2, PPIase, PPIase FKBP1A, Protein kinase C inhibitor 2, Rotamase,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified