SNX1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91265-50, BS91265-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q13596(Human) Q99N27(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC, IF, IHC, FC

All Applications: WB:1:1,000-1:2,000
ICC/IF:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: Sorting nexin 1 (SNX1) is a member of a large family of hydrophilic proteins that interact with a variety of receptor types and are involved in intracellular trafficking. SNX1 and the related splice variant, SNX1A, bind the epidermal growth factor (EGF) receptor, facilitate its transport to lysosome, and thereby contribute to the degradation of the receptor. SNX2 and SNX4 share a high degree of amino acid similarity with SNX1, as they all contain a characteristic phox homology (PX) domain. These proteins are all partially associated with cellular membranes, and they, likewise, associate with EGF, PDGF and insulin receptor tyrosine kinases. These nexins are widely expressed and yet have various tissue distribution patterns. Additionally, the sorting nexins can associate with each other and with a variety of other cellular proteins, suggesting that they exist as part of multisubunit complexes. The related protein, SNX3, comprises a distinct subgroup of nexins that share less sequence similarity outside of the PX domain and have dramatically different binding affinities for the tyrosine kinase receptors.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: SNX1 polyclonal antibody detects endogenous levels of SNX1 protein.

Bioworld Molecular Weight: 63 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of SNX1 on human skin tissue lysate using anti-SNX1 antibody at 1/2,000 dilution., ICC staining SNX1 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: SNX1, HsT17379, MGC8664, SNX 1, SNX 1a, Snx1, SNX1, SNX1A, Sorting nexin 1, Sorting nexin 1A, Sorting nexin-1, Vps5,

Immunogen: Recombinant protein within human SNX1 aa 50-250.

Conjugate: Unconjugated

Modification: Unmodified