ATG5 Rabbit rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20826-50, ES20826-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015],

Alternate Name: Autophagy protein 5 (APG5-like; Apoptosis-specific protein)

Source: Rabbit

Applications: WB; IHC; IF

Dilution: IHC-p 1:50-300, WB 1:500-2000

Reactivity: Human; Mouse; Rat

Immunogen: Recombinant Protein of ATG5

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 32kD

Human Gene ID: 9494

Human SWISS Prot NO: Q9H1Y0

Subcellular Location: Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.

Research Use Only