Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.

Product information

CAS Number: 1186430-60-3

Molecular Weight: 389.47

Formula: C23H24FN5

Chemical Name: 1-[(4-fluorophenyl)methyl]-2-[4-(4-methyl-1H-pyrazol-1-yl)piperidin-1-yl]-1H-1,3-benzodiazole

Smiles: CC1C=NN(C=1)C1CCN(CC1)C1=NC2=CC=CC=C2N1CC1C=CC(F)=CC=1

InChiKey: YGQQBKYVKLZEMA-UHFFFAOYSA-N

InChi: InChI=1S/C23H24FN5/c1-17-14-25-29(15-17)20-10-12-27(13-11-20)23-26-21-4-2-3-5-22(21)28(23)16-18-6-8-19(24)9-7-18/h2-9,14-15,20H,10-13,16H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Antihistamine-1 (Compound 2) is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.

Products are for research use only. Not for human use.